Methylisopropylcarbinolurethane and process of making same.



UNTTED STATES PATENT OFFICE.

OTTO BONHOEFFER, OF ELBERFELD, GERMANY, ASSIGNOR TO THE FAR- BENFABRIKENOF ELBERFELD 00., OF NEW YORK, N. Y.

MEI'HYLISOPROPYLCARBINOLURETHANE AND PROCESSOF MAKING SAME.

SPECIFICATION forming part of Letters Patent N 0. 675,539, dated June 4,1901, Application filed October 23, 1899. Serial No. 734,543.(Specimens) To aZZ whom it may concern:

Be it known that I, OTTO BONHOEFFER, doctor of philosophy and chemist,of Elberfeld, Germany, (assignor to the FARBENFABRIKEN on ELBERFELDCOMPANY, of New York,) have invented a new and useful Improvement inMethylisopropylcarbinolurethane and Process of Making Same, of which thefollowing is a specification;

My invention relates to the preparation of a new pharmaceutical productwhich is chemically Inethylisopropylcarbinolurethane or carbamic etherof 1nethylisopropylcarbinol having the formula and which possessesValuable therapeutic, especially soporific, properties.

The process for producing my new compound consists in allowing urea orsalts thereof to act on methylisopropylcarbinol in a suit able manner.

In order to carry out my process practically, I can, for instance,proceed as follows: Fifteen parts, by weight-,- ofmethylisopropylcarbinol are mixed with twenty-one parts, by weight, ofurea nitrate,- and the resulting mixture is heated in a closed vesselunder pressure for, say, five hours at from about 125 to 130 centigrade.After cooling the mass is extracted by means of ether or benzene, andthe so obtained solution is then evaporated. The residue which remainstherefrom represents the methylisopropylcarbinolurethane. Whenrecrystallized from ligroin, it forms white needles melting at from 8%"to 85 centigrade. It is soluble in water and dissolves readily inalcohol, benzene, ether, and in hot ligroin.

According to my investigations the new compound possesses valuabletherapeutic properties and can be used in medicine as a soporific, anaverage dose being between two and three grams.

Having now described my invention and in what manner the same is to beperformed what I claim as new, and desire to secure by Letters Patent,is

1. The process for the production of me thylisopropylcarbinolurethanewhich process consists in causing urea nitrate to act onmethylisopropylcarbinol, isolating the soiormedmethylisopropylcarbinolurethane and subsequently purifying the same,substantially as hereinbefore described.

2. As a new article of manufacture the methylisopropylcarbiuolurethanehaving the formula.

on oH/ oH.o.oo.Nrr,

forming when crystallized from ligroin white needles melting at from 84to 85 centigrade, being readily soluble in alcohol, benzene, ether andin hot ligroin, also soluble in Water and adapted for being used inmedicine as soporific, substantially as hereinbefore described.

In testimony whereof I have signed my name in the presence of twosubscribing witnesses.

R. E. JAHN, Orro KONIG.

